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Details of the Faculty or Staff
Name  
Wen Liu
Title  
  
Highest Education  
  
Office  
  345 Lingling Road, Shanghai
Phone  
  021-54925111
Zip Code  
  200032
Fax  
  021-64166128
Email  
  wliu@mail.sioc.ac.cn

Education and Appointments:
2003–present: Professor, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China 2001-2003: Research Associate, School of Pharmacy, University of Wisconsin-Madison, United States 2000–2001: Postdoctoral Fellow, Department of Chemistry, University of California, Davis, United States 1994-2000: M.S. & Ph.D., Chinese Academy of Medical Sciences (Peking Union Medical College), China 1988-1992: B.S., Sichuan University, China

Research Interest:
Natural Product Biosynthesis (Genetics, Biochemistry and Chemistry)  Combinatorial Biosynthesis for Production Improvement and Structural Diversity  Genome Mining for Discovery of Novel Microbial Natural Products
Public Services:

Honors:
2005: Distinguished Young Scholar Funded by CNSF 2005: Pujiang Scholar Funded by STCSM 2005: Rising-Star Scholar Funded by STCSM
Selected Publication:
1.Jia, X.; Tian, Z.; Shao, L.; Qu, X.; Zhao, Q.; Tang, J.; Tang, G.; Liu, W. Cloning, sequencing and genetic characterization of the Chlorothricin gene cluster from Streptomyces antibioticus DSM 40725 as a model for spirotetronate antibiotic biosynthesis. Chem. & Biol. 2006, 13,575-585.

2.Shao, L.; Qu, X.; Jia, X.; Zhao, Q.; Tian, Z.; Wang, M.; Tang, G.; Liu, W. Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase. Biochem. Biophys. Res. Commun. 2006, 345, 133-139.

3.Li, L.; Deng, W.; Song, J.; Ding, W.; Zhao, Q.; Peng, C.; Song, W.; Tang, G.; Liu, W. Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a NRPS system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. J. Bacteriol. 2008, 190, 251-263.

4.Chen, Y.; Deng, W.; Wu, J.; Qian, J.; Chu, J.; Zhuang, Y.; Zhang, S.; Liu, W. Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in fermentation of Saccharopolyspora erythraea. Appl. Environ. Microbiol. 2008, 74, 1820-1828.

5.Fang, J.; Zhang, Y.; Huang, L.; Jia, X.; Zhang, Q.; Zhang, X. Tang, G.; Liu, W. Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved stratety fro tetronate biosynthesis in spirotetronate antibiotics. J. Bacteriol. 2008, 190, 6014-6025.

6.Zhao, Q.; He, Q.; Ding, W.; Tang, M.; Kang, Q.; Yu, Y.; Deng, W.; Zhang, Q.; Fang, J.; Tang, G.; Liu, W. Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis. Chem. & Biol. 2008, 15, 693-705 (Featured in: Antibiotic biosynthesis: from Genes to Enzymes. Nature China 2008, doi:10.1038/nchina.2008.196).

7.He, Q.; Jia, X.; Tang, M.; Tian, Z.; Tang, G.; Liu, W. Dissection of two transfer reactions centered on acyl-S-carrier protein intermediates for incorporating 5-chloro-6-methyl-O-methylsalicyclic acid into chlorothricin. ChemBioChem 2009, 10, 813-819.

8.Liao, R.; Duan, L.; Lei, C.; Pan, H.; Ding, Y.; Zhang, Q.; Chen, D.; Shen, B.; Yu, Y.; Liu, W. Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. Chem. & Biol. 2009, 16, 141-14 (Featured in: Biosynthetic pathway for the production of thiopeptide antibiotics. SciBX 2(10), 2009, Doi: 10.1038/scibx.2009.423).

9. Liu, W. & Yu, Y. Combinatorial Biosynthesis of pharmaceutical natural products. Ed. By Tao, J. & Lin, G. Biocatalysis for the pharmaceutical industry-discovery, development and manufacturing. John Wiley & Sons Pte Ltd, 2009, pp229-245.


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