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Details of the Faculty or Staff
Name  
Chunyang Cao
Title  
  
Highest Education  
  
Office  
  345 Lingling Road, Shanghai
Phone  
  021-54925491
Zip Code  
  200032
Fax  
  021-64166128
Email  
  ccao@mail.sioc.ac.cn

Education and Appointments:

2006–present: Professor, State Key Laboratory of Bioorganic Chemistry, Shanghai Institute of Organic CAS

2005-2006: Salk Institute for Biological Studies, Sandiago, Washington D.C., USA

2001-2005: Johns Hopkins Medical School, Baltimore, Maryland, USA

1998-2001: Ph.D., Shanghai Institute of Organic Chemistry, CAS,


Research Interest:

Health and diseases directed chemical biology and structure biology mainly by NMR

Mechanism on the expression of neuron stem cell repressed by dsDNA and activated by small dsRNA  

DNA base methylation damage and repair

HIV-1 virus infection and DNA deamination

DNA backbone sulfur modification

Mechanism on how protein is transported correctly

Histone modification and its specific recognition

Novel method development on protein expression and structure determination

Public Services:

Honors:
2008年 入选上海市“浦江人才”
2011年 获“王天眷基金波谱奖”
Selected Publication:

1) Hou, XF#, Song YJ#, Cao C*, Tang GL*, et al, Enzymology of Anthraquinone-g-Pyrone Ring Formation in Complex Aromatic Polyketides Biosynthesis, Angew Chimie Int Ed, 2018, accepted (# Co-first Author)

2) Liu HH, Lan WX, Cao C*, Gan JH*, et al, High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads, Nucleic Acid Res, 2018, accepted

3) Wang YT, Lan WX, Cao C*, et al, Solution structure of extracellular loop of human β4 subunit of BK channel and its biological implication on ChTX sensitivity, Sci Rep, 2018, 8: 4571

4) Liu YP#, Lan WX#, Cao C*, et al, A putative G-quadruplex structure in the proximal promoter of VEGFR-2 has implications for drug design to inhibit tumor angiogenesis, J. Biol. Chem. 2018 293: 8947.

5) Fang J#, Cheng JD#, Wang, JL#, Yang HR*, Cao C*, Xu YH*, et al, Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition.,Nat Commun, 2016, 711197.

6) Lan WX, Hu ZP, Cao C*, et al, Structural investigation into physiological DNA phosphorothioate modification. Sci Rep, 2016, 6, 25737.

7) Shen J, Yang ZZ, Cao C*, et al, NMR studies on the interactions between yeast Vta1 and Did2 during the multivesicular bodies sorting pathway. Sci Rep, 2016, 6, 38710~38710

8) Lu XX, Zhang TL, Cao C*, et al, Crystalstructure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA, J Biol Chem, 2015, 290(7), 4010-21.

9) Liu SS, Guo H, Liu W*, Cao C*, et al, Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis, Sci Rep, 2015, 5, 12744.

10) Lan WX, Wang ZH, Cao C* Huang ZX*, et al, Structural Basis for Cytochrome c Y67H Mutant to Function as a Peroxidase, PLos One, 2014, 9(9),

11) Zhang Y, Lan WX, Xu, YH*, Cao C*, et al, The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B, Protein & Cell, 2014, 5(11), 837~850

12) Lan WX, Wang ZH, Huang ZX*, Cao C*, et al, Structural Basis for Cytochrome c Y67H Mutant to Function as a Peroxidase, PLos One, 2014, 9(9),

13) Liu SS, Zhang W, Dong YH*, Cao C*, et al, NMR structure of the N-terminal-most HRDC1 domain of RecQ helicase from Deinococcus radiodurans,FEBS Letters, 2013, 587(16), 2635~2642

14) Zhu S, Peigneur G, Cao C*, Tytgat J*, et al, Evolutionary Diversification of Mesobuthus α-Scorpion Toxins Affecting Sodium Channels,Mol Cell Proteomics,2012, 11(1):M111.012054~M111.012054.

15) Hu W, Wang CK, Cao C*, et al, Structural insights into DndE from Escherichia coli B7A involved in DNA phosphorothioation modification,Cell Research,2012, 22(7):1203~1206.

16) Yang ZZ, Vild C, Cao C*, Xu Z*, et al, Structural Basis of Molecular Recognition between ESCRT-III-like Protein Vps60 and AAA-ATPase Regulator Vta1 in the Multivesicular Body Pathway,J Biol Chem, 2012, 287(52):43899~43908.

17) Wang CK , Shen J , Yang ZZ, Cao C*, Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger,Cell Research,2011, 1(9):1379~1382.

18) Tong XT , Lan WX, Cao C*, et al, Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence,Nucleic Acids Research,2011, 39(15):6753~6763.

19) Yang Z, Zhang L, Cao C*, Wang XN*, et al, Highly Efficient Production of Soluble Proteins from Insoluble Inclusion Bodies by a Two-Step-Denaturing and Refolding Method,PLos One, 2011, 6(7) e22981.

20) Lan WX, Wang ZH, Huang ZX, Cao C*, et al, Conformational Toggling of Yeast Iso-1-Cytochrome c in the Oxidized and Reduced States, PLoS One. 2011; 6(11): e27219.


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