1.         Wang, F.; Zhang, W.-H.; Zhao, J.; Kang, W.-J.; Wang, S.; Yu, B.; Pan, H.-X.*; Tang, G.-L.* Characterization of miharamycin biosynthesis reveals a hybrid NRPS-PKS to synthesize high-carbon sugar from a complex nucleoside. J. Am. Chem. Soc. 2020, 142, 10.1021/jacs.0c01778.

2.         Jin, W.-B.; Wu, S.; Xu, Y.-F.; Yuan, H.*; Tang, G.-L.* Recent advances in HemN-like radical S-adenosyl-L-methionine enzyme-catalyzed reactions. Nat. Prod. Rep. 2020, 37, 17-28.

3.         Ji, Z.-Y.; Nie, Q.-Y.; Yin, Y.; Zhang, M.; Pan, H.-X.; Hou, X.-F.*; Tang, G.-L.* Activation and characterization of cryptic gene cluster: Two series of aromatic polyketides biosynthesized by divergent pathways. Angew. Chem. Int. Ed. 2019, 58, 18046-18054.

4.         Zhang, Y.; Wen, W.-H.; Pu, J.-Y.; Tang, M.-C.; Zhang, L.; Pen, C.; Xu, Y.; Tang, G.-L.* Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 2018, 115, 11232–11237.

5.         Hou, X.-F.; Song, Y.-J.; Zhang, M.; Lan, W.; Meng, S.; Wang, C.; Pan, H.-X.; Cao, C.*; Tang, G.-L.* Enzymology of anthraquinone-g-pyrone ring formation in complex aromatic polyketide biosynthesis. Angew. Chem. Int. Ed. 2018, 57, 13475-13479.

6.         Jin, W.-B.; Wu, S.; Jian, X.-H.; Yuan, H.*; Tang, G.-L.* A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis. Nat. Commun. 2018, 9, 2771.

7.         Meng, S.; Han, W.; Zhao, J.; Jian, X.-H.; Pan, H.-X.*; Tang, G.-L.* A six-oxidase cascade for tandem C-H bond activation revealed by reconstitution of bicyclomycin biosynthesis. Angew. Chem. Int. Ed. 2018, 57, 719-723.

8.         Yuan, H.; Zhang, J.; Cai, Y.; Wu, S.; Yang, K.; Stephen Chan, H. C.; Huang, W.; Jin, W.-B.; Li, Y.; Yin, Y.; Igarashi, Y.; Yuan, S.*; Zhou, J.*; Tang, G.-L.* GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection. Nat. Commun. 2017, 8, 1485.

9.         Song, L.-Q.; Zhang, Y.-Y.; Pu, J.-Y.; Tang, M.-C.; Peng, C.; Tang, G.-L.* Catalysis of extracellular deamination by a FAD-linked oxidoreductase after prodrug maturation in the biosynthesis of saframycin A. Angew. Chem. Int. Ed. 2017, 56, 9116-9120.

10.     Zhang, Z.; Gong, Y.-K.; Zhou, Q.; Hu, Y.; Ma, H.-M.; Chen, Y.-S.; Igarashi, Y.; Pan, L.*; Tang, G.-L.* Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade. Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 1554–1559.

11.     He, H.-Y.; Yuan, H.; Tang, M.-C.; Tang, G.-L.* An unusual dehydratase acting on glycerate and a ketoreducatse stereoselectively reducing α-ketone in polyketide starter unit biosynthesis. Angew. Chem. Int. Ed. 2014, 53, 11315-11319.

12.     He, H.-Y.; Tang, M.-C.; Zhang, F.; Tang, G.-L.* Cis-Double bond formation by thioesterase and transfer by ketosynthase in FR901464 biosynthesis. J. Am. Chem. Soc. 2014, 136, 4488-4491.

13.     Xu, H.; Huang, W.; He, Q.-L.; Zhao, Z.-X.; Zhang, F.; Wang, R.; Kang, J.; Tang, G.-L.* Self-resistance to antitumor antibiotic: a DNA glycosylase triggers the base excision repair system in yatakemycin biosynthesis. Angew. Chem. Int. Ed. 2012, 51, 10532-10536.

14.     Huang, W.; Xu, H.; Li, Y.; Zhang, F.; Chen, X.-Y.; He, Q.-L.; Igarashi, Y.; Tang, G.-L.* Characterization of yatakemycin gene cluster revealing a radical SAM-dependent MT and highlighting spirocyclopropane biosynthesis. J. Am. Chem. Soc. 2012, 134, 8831-8840.

15.     Peng, C.; Pu, J.-Y.; Song, L.-Q.; Jian, X.-H.; Tang, M.-C.; Tang, G.-L.* Hijacking a hydroxyethyl unit from a central metabolic ketose into a nonribosomal peptide assembly line. Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 8540-8545.

16.     Zhang, F.; He, H.-Y.; Tang, M.-C.; Zhou, Q.; Tang, G.-L.* Cloning and elucidation of the FR901464 gene cluster revealing a complex AT-less PKS using glycerate as starter units. J. Am. Chem. Soc. 2011, 133, 2452-2462.