1、前过渡金属锆、钛杂环化合物促进的高选择性合成反应研究。

2、过渡金属与烯烃、炔烃、共轭多炔类化合物的配位行为与反应性能研究。

3、过渡金属催化的高效串联反应研究。

4、金（gold）催化的碳-碳键与碳-杂原子键的形成反应。

5、含有p-共轭体系的有机功能材料的设计与合成。

1.Highly Stereoselective Synthesis of Trisubstituted cis-[3]Cumulenols from Alkynylated Oxatitanacycles in the Presence of Lewis acids, Chen, J.; Liu,* Y. Organometallics 2010, 29, 505.

2.Gold-catalyzed Intramolecular Indole/Alkyne Cyclization Cascades through a Heterolytic Fragmentation: 1,5-Indole Migration and Allenylation, Li, G.; Liu,* Y. J. Org. Chem. 2010, 75, 3526.

3.Aldehyde Addition to 1,3-Butadiyne-Derived Zirconacyclocumulenes: Stereoselective Synthesis of cis-[3]Cumulenols, Fu, X.; Liu,* Y.;  Li*, Y. Organometallics 2010, 29, 3012.

4.Diverse Reactivity of Zirconacyclocumulenes Derived from Coupling of Benzynezirconocenes with 1,3-Butadiynes towards Acyl Cyanides: Synthesis of Indeno[2,1-b]pyrroles or [3]Cumulenones. Fu, X.; Chen, J.; Li, G.; Liu,* Y. Angew. Chem. Int. Ed. 2009, 48, 5500.

5.Gold-Catalyzed Cascade Friedel-Crafts/Furan-Alkyne Cycloisomerizations for the Highly Efficient Synthesis of Arylated (Z)-Enones or –Enals. Chen, Y.; Lu, Y.; Li, G.; Liu,* Y. Org. Lett. 2009, 11, 3838.

6.Stereoselective Synthesis of β-Hydroxyallenes with Multiple Contiguous tereogenic Centers via Aldehyde Addition to a-alkenyl-Substituted irconacyclopentenes. Zhou, Y.; Chen, J.; Zhao, C.; Wang, E.; Liu,* Y.; Li,* Y. J. Org. Chem. 2009, 74, 5326.

7.Gold-Catalyzed Intermolecular Reactions of (Z)-Enynols with Indoles for the Construction of Dihydrocyclohepta[b]indole Skeletons through a Cascade Friedel–Crafts/Hydroarylation Sequence. Lu, Y.; Du, X.; Jia, X.; Liu,* Y. Adv. Synth. Catal. 2009, 351, 1517.

8.New Synthetic Approach for the Construction of Multi-Substituted 2-Acyl Furans via IBX-Mediated Cascade Oxidation/Cyclization of cis-2-En-4-yn-1-ols. Du, X.; Chen, H. ; Liu,* Y. Chem. Eur. J. 2008, 14, 9495.

9.Gold-Catalyzed Multicomponent Synthesis of Aminoindolizines from Aldehydes, Amines and Alkynes Under Solvent-Free Conditions or in Water. Yan, B.; Liu,* Y. Org. Lett. 2007, 9, 4323.

10.General and Direct Synthesis of 3-Aminoindolizines and Their Analogues via Pd/Cu-Catalyzed Sequential Cross-Coupling/Cycloisomerization Reactions. Liu,* Y.; Song, Z.; Yan, B. Org. Lett. 2007, 9, 409.

11.Highly Stereoselective Synthesis of TMS-, Alkyl-, or Aryl Substituted cis-[3]cumulenols via a-alkynylated zirconacyclopentenes. Liu,* Y.; Gao, H.; Zhou, S. Angew. Chem. Int. Ed. 2006, 45, 4163.