网站地图邮箱登陆 English version中国科学院
 
 
  研究队伍
  · 院士专家
 
  · 研究员
 
  · 杰出青年
 
  · 副研究员
 
  · 人才招聘
 
 
您的位置: 首页>研究队伍>人才
姓 名:
 李征
性 别:
 女
职 称:
 副研究员
学 历:
 博士研究生
电 话:
 021-68582307
传 真:
 
电子邮件:
 zhengli@sioc.ac.cn
个人主页:
 
通讯地址:
 上海市零陵路345号 200032

简历:

2005.8-2010.6:中国科学院上海药物研究所,博士

2001.9-2005.7:河北大学,学士

2016.1-至今,上海有机所生命有机国家重点实验室

2015.1-2015.7,艾伯维医药公司中国研发中心,高级研究员;

2012.2-2014.12,美国加州大学洛杉矶分校,助理研究员;

2010.6-2010.12 哈佛大学化学与化学生物学系,博士后,导师:Prof. Yoshito Kishi


研究方向:

药物化学与化学生物学。基于靶向的药物设计与合成,重点关注肿瘤疾病、免疫系统疾病、神经退行性疾病等疾病领域的药物研究。


专家类别:
副研究员

职务:

社会任职:

获奖及荣誉:
代表论著:

¨       Xia, Shanghua; Gan, Lu; Wang, Kailiang; Li, Zheng; Ma, Dawei*.Copper-Catalyzed Hydroxylation of (Hetero)aryl Halides under Mild Conditions. J. Am. Chem. Soc., 2016, 138, 13493?13496.

¨       Nomme, Julian#; Li, Zheng #; Gipson, Raymond M.; Wang, Jue; Armijo, Amanda L.; Le, Thuc; Poddar, Soumya; Smith, Tony; Santarsiero, Bernard D.; Nguyen, Hien-Anh; Czernin, Johannes; Alexandrova, Anastassia; Jung, Michael E.; Caius G. Radu,* and Arnon Lavie*. Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability. J. Med. Chem. 2014, 57, 9480-9494.

¨       Nathanson, David A.; Armijo, Amanda L.; Tom,  Michelle; Li, Zheng; Austin, Wayne R.; Nomme, Julian; Campbell, Dean O.; Dimitrova, Elizabeth; Lee, Jason T.; Ta, Lisa; Darvish, Ryan; Gordin, Ari; Wei, Liu; Liao, Hsiang-I; Wilks, Moses; Martin, Colette; Tsoi, Jennifer; Hong, Aayoung; Sadeghi, Saman;  Murphy, Jennifer M.; Boulo, Nidal; Phelps, Michael E.; Faull, Kym F.; Herschman, Harvey R.;  Jung, Michael E.; Czernin, Johannes; Lavie, Arnon;  and Radu, Caius G. *. Co-Targeting of convergent, switchable nucleotide biosynthetic pathways induces synthetic lethality in leukemia. J. Exp. Med., 2014, 211, 473-486.

¨       Murphy, Jennifer M.; Armijo, Amanda L.; Nomme, Julian; Lee, Chi Hang; Smith, Quentin A.; Li, Zheng; Campbell, Dean O.; Liao, Hsiang-I; Nathanson, David A.; Austin, Wayne R.; Lee, Jason T.; Darvish, Ryan; Wei, Liu; Wang, Jue; Su, Ying; Damoiseaux, Robert; Sadeghi, Saman;  Phelps, Michael E.; Herschman, Harvey R.; Czernin, Johannes; Alexandrova, Anastassia N.; Jung, Michael E.; Lavie, Arnon*; and Radu, Caius G.* Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J. Med. Chem., 2013, 56, 6696-6708.

¨       Deng, Gang; Huang, Zuo-gang; Zhao, Xiao-long; Li, Zheng; Li, Yuan-chao; Jiang, Biao*. Stereospecific Synthesis of Drospirenone. Chinese Journal of Chemistry, 2013, 31, 15-17.

¨       Zhou, Zhao-Li; Luo, Zhi-Guo; Yu, Bing; Jiang, Yi; Dai, Mei; Tong, Lin-Jiang; Li, Zheng; Li, Yuan-Chao; Ding, Jian; Miao, Ze-Hong*. Increased accumulation of hypoxia-inducible factor-1alpha with reduced transcription activity mediates the antitumor effect of triptolide. Molecular Cancer, 2010, 9, 268.

¨       Yang, Ya-Xi; Li, Zheng; Feng, Hui-Jin; Chen, Guo-Rong; Li, Yuan-Chao*. Concise synthesis of ?ve-membered ring carbasugars based on key ring-closing metathesis. Tetrahedron Letters, 2010, 51, 3848-3851.

¨       Li, Zheng; Zhou, Zhao-Li; Miao, Ze-Hong; Lin, Li-Ping; Feng, Hui-Jin; Tong, Lin-Jiang; Ding, Jian*, and Li, Yuan-Chao*. Design, synthesis, and antitumor evaluation of novel triptolide derivatives as potential anticancer agents. J. Med. Chem., 2009, 52, 5115-5123.

¨       Li, Zheng; Li, Yuan-Chao*. Structural diversity and structure-activity relationship - new drug research and development of Tripterygium wilfordii Hook.f. Progress in Chemistry, 2009, 21, 2483-2491.

¨       Li, Zheng; Deng, Gang; Li, Yuan-Chao*. ZnI2/Et3SiH: A novel mild reduction system for direct deoxygenation of aryl aldehydes, ketones, and α,β-unsaturated enones. Synlett, 2008, 3053.

¨       Deng, Gang; Li, Zheng; Peng, Shu-Ying; Fang, Li; Li, Yuan-Chao*. A new route to stereoselective construction of 6, 7-methylene unit from androst-5-en-7-one. Tetrahedron, 2007, 63(22), 4630-4635.

版权所有:中国科学院上海有机化学研究所 Copyright © 2002-2009
地址:中国.北京 京ICP备05002791号